Monthly Archives: March 2020

False declare: UK authorities sending fines by textual content message for breaching lockdown guidelines

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Posts being shared on social media (instance right here) make the declare that the UK authorities is issuing fines to folks through textual content in the event that they depart their properties a number of occasions a day.

This declare comes after British Prime Minister Boris Johnson on Monday (March 23) ordered folks to remain at residence to assist stem the unfold of the coronavirus. Below the curbs on motion, Britons have been instructed to depart residence just for very restricted causes, together with going to supermarkets for important provides or for train as soon as a day.

The publish accommodates a picture displaying two textual content messages apparently from the sender ‘UK_GOV’ studying:

“GOV.UK CORONAVIRUS ALERT New guidelines in power now: you have to keep at residence. Extra information & exemptions at gov.uk/coronavirus Keep at residence. Defend the NHS. Save lives.”

“You could have been outdoors of your own home 3 occasions right now, you might be in breach of presidency pointers. Your £30 positive might be added to your invoice.”

The British authorities mentioned in a press release on March 24 {that a} textual content similar to the primary could be despatched to all members of the general public with a registered cellphone quantity (right here).

The Prime Minister’s workplace confirmed to Reuters that just one textual content message had been despatched, and that any others claiming to be from the British authorities have been pretend (right here).

“UK Authorities has despatched out just one textual content message on new guidelines about staying at residence to forestall the unfold of #coronavirus (see under). Should you see others claiming to be from UK Authorities, they’re false,” a press release posted on the No 10 Press Workplace Twitter on March 25 mentioned.

The brand new measures state that the general public ought to keep at residence except for one of many following causes (right here

Purchasing for fundamental requirements, for instance meals and medication, which should be as rare as doable.

One type of train a day, for instance a run, stroll, or cycle – alone or with members of your family.

Any medical want, or to offer care or to assist a weak particular person.

Travelling to and from work, however solely the place this positively can’t be finished from residence.

Aside from train, which is restricted to as soon as a day, members of the general public are usually not restricted to what number of occasions they depart the home for causes accredited by the federal government. Nevertheless, Britons are requested to make buying as rare as doable.

The federal government has introduced that those that don’t adjust to the principles might obtain a £30 positive, nevertheless these could be spot fines from police, and never fines delivered by textual content.(right here)

VERDICT

False: the UK authorities has not despatched residents textual content messages to inform them they’ve been fined for breaching nationwide lockdown guidelines. It is a hoax screenshot.

This text was produced by the Reuters Truth Test staff. Learn extra about our reality checking work right here .



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COVID-19 vaccine tracker | RAPS

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Posted 06 Might 2022 | By Jeff Craven 

COVID-19 vaccine tracker
The worldwide endeavor to create a protected and efficient COVID-19 vaccine is bearing fruit. Dozens of vaccines now have been licensed or authorised across the globe; many extra stay in improvement.
 
To make clear the panorama for our readers, our vaccine tracker has been cut up in two. The primary chart particulars vaccine candidates which are nonetheless in improvement to handle the shortage of vaccines and entry in lots of international locations around the globe; the second chart lists vaccines which are licensed or authorised by a number of nation. To disclose in-depth details about every candidate, choose the “Particulars” button above the chart or click on on the inexperienced plus button subsequent to every entry.
 
Details about the unprecedented public/non-public partnerships spawned by the COVID-19 public well being emergency now could be discovered under the charts.
 
Our charts are up to date each different week. For those who want to submit an replace or discover a problem with this knowledge, please e-mail Focus at [email protected] 

Up to date 06 Might with new data on vaccines from Pfizer/BioNTech, Moderna, Bharat Biotech, Zydus Cadila, Novavax, Medicago and Valneva.


 

Vaccine candidates in improvement

 

 

Approved/authorised vaccines

 

 

 

COVID-19 vaccine initiatives

OWS: Operation Warp Velocity is a collaboration of a number of US authorities departments together with Well being and Human Companies (HHS) and subagencies, Protection, Agriculture, Vitality and Veterans Affairs and the non-public sector. OWS has funded JNJ-78436735 (Janssen), mRNA-1273 (Moderna), and NVX‑CoV2373 (Novavax), V590 (Merck/IAVI), V591 (Merck/Themis), AZD1222 (AstraZeneca/College of Oxford), and the candidate developed by Sanofi and GlaxoSmithKline.
 
OWS is “a part of a broader technique to speed up the event, manufacturing, and distribution of COVID-19 vaccines, therapeutics, and diagnostics.” 
 
ACTIV: Inside OWS, the US Nationwide Institutes of Well being (NIH) has partnered with greater than 18 biopharmaceutical firms in an initiative referred to as ACTIV. ACTIV goals to fast-track improvement of drug and vaccine candidates for COVID-19.
 
COVPN: The COVID-19 Prevention Trials Community (COVPN) combines scientific trial networks funded by the Nationwide Institute of Allergy and Infectious Ailments (NIAID): the HIV Vaccine Trials Community (HVTN), HIV Prevention Trials Community (HPTN), Infectious Ailments Scientific Analysis Consortium (IDCRC), and the AIDS Scientific Trials Group.
 
COVAX: The COVAX initiative, a part of the World Well being Group’s (WHO) Entry to COVID-19 Instruments (ACT) Accelerator, is being spearheaded by the Coalition for Epidemic Preparedness Improvements (CEPI); Gavi, the Vaccine Alliance; and WHO. The aim is to work with vaccine producers to supply low-cost COVID-19 vaccines to international locations. CEPI’s candidates from firms Inovio, Moderna, CureVac, Institut Pasteur/Merck/Themis, AstraZeneca/College of Oxford, Novavax, College of Hong Kong, Clover Biopharmaceuticals, and College of Queensland/CSL are a part of the COVAX initiative. The US joined COVAX on 21 January. Probably the most up-to-date forecast of COVAX’s vaccine provide could be discovered right here. An interim distribution forecast, most not too long ago printed 3 February, could be discovered right here.
 

 

© 2022 Regulatory Affairs Professionals Society.


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France’s Tradition Minister Has Entered Quarantine After Testing Constructive for Coronavirus

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French Tradition Minister Franck Riester has self-quarantined after testing optimistic for Covid-19, or coronavirus. The politician started displaying signs yesterday, the ministry confirmed, forward of scheduled conferences to evaluation measures put in place to restrict the unfold of the an infection.

Riester is in quarantine at residence however is reportedly “feeling positive,” in line with his submit on Fb in the present day. “I’m affected by the traditional flu signs in the present day,” he wrote, including that he’s working remotely. The 46-year-old politician had spent a number of work days final week sitting within the Nationwide Meeting, the place 5 instances of the virus have been confirmed. French president Emmanuel Macron had not met along with his tradition minister in a number of days, though he was in attendance on the meeting.

The information brings into the main focus the truth that politicians, who by the character of their work have to ceaselessly meet in giant conferences and make public appearances, are on the frontlines of the illness. France’s head of state inspired his cupboard to take the identical precautions as all French individuals to reduce the unfold of an infection.

Riester clarified that the didn’t attend conferences as soon as it grew to become clear that there had been an outbreak on the Nationwide Meeting.

France is certainly one of Europe’s most affected nations after Italy, which has now prolonged journey restrictions throughout the entire nation in an effort to curb the unfold of the virus.

As of writing, France has 1,412 confirmed instances and 30 deaths. The federal government has taken actions to try slowing the speed of an infection, together with the banning of gatherings over 1,000 individuals. Festivals, concert events, and soccer video games have been canceled, postponed, or are being streamed on-line with out attendant audiences.

Riester had deliberate to satisfy with representatives from the cinema and performing arts industries in the present day, March 10, to evaluate the efficacy of recent security measures being taken, The Artwork Newspaper studies.

The Louvre reopened final week with up to date safety measures after a number of days of closure because the museum mentioned how one can shield its employees; it has gone cash-free and guards usually are not dealing with tickets. The Musée d’Orsay is regulating entrance numbers to adjust to the brand new guidelines. On the Louvre, solely these with pre-purchased tickets on-line or passes are being allowed into the museum.

Comply with Artnet Information on Fb:


Wish to keep forward of the artwork world? Subscribe to our publication to get the breaking information, eye-opening interviews, and incisive important takes that drive the dialog ahead.

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Your favourite crime exhibits hinder this life-and-death trigger (Opinion)

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Whereas the battle over “finest” rages on, an much more essential dialog is being misplaced: the affect of all the remaining. Most of the hottest exhibits hardly ever get nominated for awards and they’re hardly ever up for significant public debate. However they need to be.

Within the fall 2019 lineup, we calculated that greater than 60% of prime-time dramas on the 4 predominant broadcast networks — NBC, CBS, ABC, and FOX — have been exhibits about crime, the police and the authorized system. In keeping with knowledge supplied by Selection, exhibits like “NCIS,” “Blue Bloods,” “Chicago P.D.” and “Regulation and Order: SVU” attracted extra complete viewers than another class of present — actuality, comedy, sports activities, information or non-crime drama.
As years of analysis have proven, tv fiction can profoundly form public attitudes and even how folks behave in actual life. Over time, tv can affect how viewers assume and deal with different folks, whom they belief and even how they vote. As momentum for altering our prison justice system will increase exterior tv, we should ask, are these exhibits serving to us transfer ahead or taking us backward?
After we take into consideration what number of hours a day on common grownup Individuals spend watching TV (almost 4 ½ hours, in keeping with Nielsen’s Q1 2019 report), and the recognition of crime dramas, it is truthful to say that crime exhibits play a big position in “educating” folks concerning the prison justice system (probably greater than another single supply).
Due to a brand new report that analyzes 26 crime exhibits from the 2017-2018 season, launched by my group, Shade Of Change, in partnership with the USC Annenberg Norman Lear Middle, we are able to now conclusively say that what this style communicates to the general public about each the prison justice system and race is extremely inaccurate, problematic and dealing towards help for prison justice reform. That should change.
Our criminal justice system is built to inflict pain. Here's how we can heal it.

A analysis crew sampled, coded and analyzed the content material (storylines, characters, depictions of prison justice process, depictions of race and racism, and many others.) for 353 episodes throughout the style, 70-80% of the episodes for every present that season. The analysis crew additionally used a number of trade sources to analysis the police consultants every present employed, their shoot areas and the race and gender for the 42 present creators, 27 showrunners and 275 writers of the 26 exhibits examined within the 2017-2018 season. (The identical technique was used to look at the race and gender of the 215 writers for the 19 sequence that continued into the 2018-2019 season and had aired by the tip of the research interval.)

The research discovered that these exhibits largely served to normalize injustice — making injustice acceptable within the minds of viewers. Most exhibits propagated harmful misinformation about how the justice system works, made racism within the system invisible (even denying its existence), and portrayed a system that doesn’t want change or police accountability. If something, most exhibits made the argument to hundreds of thousands of viewers that police want extra energy, not much less, and that it is the accused who abuse the system somewhat than being abused by it.

The report recognized one possible explanation for problematic content material: a distressing lack of variety among the many writers, showrunners and creators who make up this style. A style that influences the general public’s fascinated about the prison justice system maybe greater than another supply — a system that impacts black folks disproportionately — should embody the voices and tales from these communities.

In one of many extra attention-grabbing findings, the research recognized what we have now labeled the Particular person of Shade Endorsement Impact: a sample of casting folks of shade as characters who rationalize immoral and unjust regulation enforcement conduct, which then makes it tougher for a viewer to see that conduct as racially biased or problematic.

The report additionally discovered that the majority of those exhibits make wrongful police conduct appear proper: presenting unlawful, unethical and immoral conduct on the a part of police and different authorities as justifiable — and even needed — whereas fastidiously rationalizing or in any other case dismissing any objections to that conduct. What the report identifies because the “Good Man” Endorser Impact is the apply of routinely depicted “good man” regulation enforcement characters partaking in unhealthy conduct, thereby making heroes out of police who break the foundations, violate our rights and trigger hurt.

A typical instance of each the “Good Man” Endorser Impact and the Particular person of Shade Endorser Impact working without delay will be seen within the first episode of Season 9 of “NCIS: Los Angeles.” Two predominant forged characters, white NCIS brokers, wish to break right into a home with out getting a warrant. They put a name into their new boss, saying “Now we’re gonna discover out what sort of boss Mosley is gonna be.” They have been delighted when Mosley, who’s black, advised them to go forward with out the warrant and to not fear concerning the regulation. The message: it is OK to interrupt the regulation and violate folks’s rights as a result of we are the good guys, and folks of shade are okay with it, too.

The report highlights a number of such scenes as consultant of a constant sample of depictions alongside the identical strains, whether or not associated to cases of torture, coercion, rolling eyes on the point out of racism or justifying racial profiling. CNN has reached out to CBS for remark.

The crime style right now is regressive: taking us backwards relating to how we take into consideration crime and punishment, and race. They’re educating the American public that justice is catching the unhealthy man, irrespective of what number of guidelines are damaged, how a lot hurt and injustice is induced to folks whereas pursuing them, and what number of instances harmless individuals are wrongly caught. With most exhibits, you’ll by no means assume that the issues police and prosecutors do trigger a
ny actual hurt in any respect.

It may very well be completely different. Often, a few of these exhibits helped the general public perceive the present debate over prison justice reform and the experiences of black folks, girls and LGBTQ people who find themselves most unjustly and routinely harmed by it. For instance, one scene in episode 13, Season 4 of “Learn how to Get Away with Homicide” (a crossover with “Scandal”) featured a strong rationalization of how the dearth of funding for public defenders permits prosecutors to coerce poor defendants — typically folks of shade — into accepting exploitative and unjust plea bargains that wreck their lives, and that the dearth of correct public protection amounted to a violation of their constitutional rights.

On this means and so many others, crime exhibits may make trustworthy drama about racial disparities and abuses (as “When They See Us” did) and introduce concepts about efficient reform which can be taking off in actual life, like different sentencing, police accountability, ending cash bail and ending racial disparities in prosecutions. (Bear in mind when crime exhibits — “Perry Mason,” “Matlock” — have been all about noble protection attorneys proving folks harmless and exposing the injustice of the system?)

We can not let community executives function with out accountability relating to the accuracy of representations of the prison justice system. And, let’s be actual, we merely can not belief community executives and producers to be accountable with none exterior strain: they revenue from the sensationalism, racist mythologies and violence these exhibits promote, and there aren’t any incentives for them to vary. The general public by no means wins when firms are left to set their very own requirements and “police themselves.” The trade should set up an impartial auditor — an outdoor workplace of specialists who can actually consider the accuracy and representations of the exhibits that make up the style, observe variety, launch common public studies and supply viable suggestions that can work for each the networks and the general public.

Society is dealing with a reckoning right now relating to the liberty to unfold misinformation. The short-run sequence “When They See Us” and “Chernobyl” present the affect of this. Hate rallies use lies to demonize folks of shade. The identical forces have carte blanche to make use of social media to mislead and persuade would-be voters. It is a mess. It is taking us backwards. We can not enable the crime style to proceed mendacity to the general public about policing and about race, as a result of black communities can not afford to go backwards on prison justice. It’s a matter of life and loss of life.

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Which Cell Tradition Media Is Proper for You?

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Relating to conducting laboratory analysis within the life sciences, scientists should create acceptable circumstances to accommodate the survival and/or progress of dwelling cells. 

Cell cultures require sure environmental circumstances. For optimum progress and proliferation, cells require:

  • Temperature management
  • Acceptable pH and osmolality
  • A substrate for mobile attachment
  • A sure kind of tradition medium
  • An incubator to keep up secure circumstances

This text will delve into one in all these essential elements: cell tradition media. We’ll clarify what cell tradition media is, what its elements are, the differing types, and what to search for when choosing an acceptable cell tradition medium. 

What’s cell tradition media?

Cell tradition media, often known as progress media, is an umbrella time period that encompasses any gel or liquid created to help mobile progress in a man-made atmosphere.

When scientists take away cells, organs, or tissues from dwelling creatures, they have to maintain them in an acceptable synthetic atmosphere. A tradition medium performs an integral position in cell tradition expertise, supporting in vitro mobile analysis.

It’s the medium that provides the vitamins vital for cell cultures to outlive and proliferate. The expansion media additionally supplies the proper osmolality and pH. 

Scientists should think about their cell kind when selecting an acceptable progress medium. There are a number of various kinds of cell tradition media that accommodate cells from mammals, crops, bugs, micro organism, yeast, viruses, and extra.

The selection of cell tradition medium instantly impacts the outcomes of an experiment, and as such, have to be rigorously thought-about. 

What are the elements of cell tradition media?

Cell tradition media are comprised of a mix of compounds and vitamins designed to help mobile progress. Widespread elements of cell tradition media embrace:

  • Amino acids: Each cell tradition media incorporates a mix of amino acids, the constructing blocks of protein. Each important and nonessential amino acids could also be used to spice up cell viability and progress. 
  • Nutritional vitamins: Nutritional vitamins are included to facilitate mobile progress and proliferation. Serum is used because the supply of many nutritional vitamins in serum-containing media, however nutritional vitamins have to be added to serum-free media. 
  • Carbohydrates: Carbohydrates present an vitality supply for dwelling cells. Glucose is often used, however different carbohydrates, similar to galactose, fructose, or maltose, can be found. 
  • Inorganic salts: Inorganic salts are wanted to manage membrane potential and osmolality.
  • Fundamental and hint parts: Cells want parts like iron, potassium, magnesium, and zinc to develop. 
  • Serum: Serum incorporates progress components and inhibitors, hormones, protease inhibitors, chelators, amino acids, carbohydrates, lipids, nutritional vitamins, hint parts, minerals, and extra which might be wanted for mobile progress. Bovine serum is often used. 
  • Hormones: Sure hormones could also be added to affect cell operate, progress, and proliferation. 
  • Buffering techniques: Buffering techniques regulate pH.
  • Dietary supplements: Dietary supplements like hormones, enzyme inhibitors, and hint parts are typically added to cell tradition media that cater to the cell-type and analysis objective.
  • Antibiotics: Antibiotics are added to cell tradition media to inhibit fungal and bacterial progress. Antibiotics are finest fitted to serum media due to proteins that bind a few of the antibiotic load. In distinction, cells in serum-free media are at a larger probability of antibiotic toxicity.  

What are the various kinds of cell tradition media?

Cell tradition media could be damaged into two major classes: pure media and artificial media.

Pure media

Pure media are these which might be derived from tissue extraction or animal physique fluids, similar to plasma, lymph, and serum. Pure media could be damaged down into three teams:

  • Organic fluids: Examples embrace serum, plasma, lymph, and amniotic fluid.
  • Tissue extracts: Examples embrace embryo, bone marrow, tumour, and liver extracts. 
  • Clots or coagulants: Examples embrace plasma clots and coagulants. 

Serum is the most typical pure medium. Serum is even used as a complement in artificial medium cultures. Bovine serum is common due to quite a few benefits, together with ample sources and an extended utility time. 

Artificial media

Artificial media (often known as synthetic media) are these created utilizing quite a lot of natural and inorganic compounds. Artificial media embrace:

  • Serum-containing media: Artificial media the place supplemental serum is used. 
  • Serum-free media: Serum-free media (SFM) provide larger consistency than serum-containing media, permitting researchers to help mobile progress and proliferation with out the necessity for serum.  
  • Chemically outlined media: Chemically outlined media are contamination-free, consisting of solely purified natural and inorganic elements. 
  • Protein-free media: Protein-free media include no protein. Protein dietary supplements are added on an as-needed foundation.  
  • Balanced salt options (BSS): BSS on their very own are used to maintain cells alive. BSS are enriched with vitamins and different compounds to create tradition media able to supporting mobile progress and proliferation. As such, BSS kind the muse of many sorts of complicated media. 

Serum-free media (SFM) are sometimes categorized as both primary/basal or complicated. Basal mediums are these with out dietary supplements. As soon as progress dietary supplements are added to a basal medium, it turns into a fancy medium. 

Under is an inventory of some widespread tradition media. 

Media Identify Media Kind Description
MEM (Minimal Important Medium) Basal media Often known as Eagle’s minimal important medium (EMEM), this medium is used for major and diploid cultures. MEMs include solely nutritional vitamins, non-essential amino acids, inorganic salts, and glutamine. 
DMEM (Dulbecco’s Modified Eagle’s Medium) Basal media Just like MEM, however with further amino acids and nutritional vitamins. Comprises no progress promoters or proteins.
IMDM (Iscove’s Modified Dulbecco’s Medium) Advanced media A modified model of DMEM with extra amino acids and nutritional vitamins. It incorporates no iron however does have selenium and ferric nitrate. Appropriate for high-density cultures.  
RPMI-1640  Advanced media A medium that works for many sorts of mammalian cells. One of the vital used mediums. 
Ham’s F-10 and F-12 Serum-free media Ham’s F-10 was the unique Ham nutrient combination, designed to be used with Chinese language hamster ovary (CHO) cells. It’s appropriate to be used with human diploid cells. Ham’s F-12 is extra complicated, fitted to rat prostate epithelial and rat hepatocyte cells. 

What to search for in a cell tradition media

A very powerful step is f
iguring out what kind of cell tradition medium to make use of. With so many industrial mediums out there, discovering the correct selection could be intimidating.

Begin by researching the cell line you’ll be utilizing to find out what totally different tradition mediums are really helpful. Chances are you’ll then choose a number of and check out them out to see what works finest. Listed here are some components to contemplate. 

1. Media preparation

Cell tradition media varieties are available in three kinds:

1. Powdered medium: Powdered media are the least costly however have to be sterilized and ready by the researcher. 

2. Concentrated medium: Concentrated media solely should be diluted by the researcher.

3. Working resolution: Working options are the simplest kind of media. They’re designed for use with none manipulation by the researcher. 

2. Kind of media to make use of: pure vs artificial media

All cell tradition media belong to one in all two classes: pure media or artificial media. Every has its personal professionals and cons which direct investigators on which medium to decide on.

Serum media are created by eradicating hemaleucin from plasma. The ensuing combination incorporates a mix of elements that’s precious for mobile progress and proliferation. The advantages of serum media embrace that they:

  • Include all kinds of mobile vitamins, similar to amino acids, nutritional vitamins, minerals, and fatty acids.
  • Present elements that enable for cell adherence.
  • Include quite a lot of progress components and hormones.  

However there are downsides to serum media. Relating to its drawbacks, serum media:

  • Lack compositional uniformity, making it poorly fitted to large-scale experiments. 
  • Include a mix of compounds, a few of which could be dangerous to or inhibit the expansion of sure cell sorts.
  • Have a larger danger of contamination when in comparison with synthetic media.
  • Might complicate the isolation of cell tradition merchandise. 
  • Will be costly. 

Artificial media have the distinct benefit of consistency. Investigators can make sure that they’re utilizing the identical tradition medium, even when scaling their analysis. Moreover, synthetic media are sometimes inexpensive than serum-based media.

But, there are downsides to utilizing a serum-free medium. These cultures are extra delicate to extremes, together with these of temperature, pH, and osmolality. 

3. Which particular medium to make use of

After getting chosen between pure and synthetic media, it’s essential to choose a particular medium. Many labs make the most of industrial media, permitting high quality and consistency with minimal effort.

To seek out the most effective one, it’s essential to ask your self:

  • What sorts of cells will you be utilizing, and what are their necessities?
  • What are the capabilities and limitations of your lab? 
  • What’s the objective of the experiment? 

For example, stem cells require media that may facilitate upkeep, differentiation, enlargement, and downstream functions. As a result of stem cells are pluripotent, their media circumstances have to be carefully monitored in order that investigators don’t find yourself with one thing aside from their goal. There are specific industrial media designed to be used with stem cells, similar to RPMI-1640, that work nicely with sure sorts of stem cells.

If you’re uncertain which medium is finest, media corporations may help you slender down your choices. Make certain that you perceive your cells, targets, and lab specs in order that you choose the most effective match. 

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